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Life Under Confinement

Grow Your Vision

how physico-chemical complexities of 3D environments regulate living systems across scales

I am a final year graduate student with Dr. Tapomoy Bhattacharjee at the National Centre for Biological Sciences, Bangalore. I work at the interface of soft matter biophysics, mechanobiology, and bioengineering.

My PhD research pioneers an understanding of complex environments as active regulators of living systems. I leverage the universality of physical principles to traverse across biological scales, and ask how different environmental cues and constraints affect life forms at the single cell, tissue, and organismal level.

 

To accomplish this, I engineer sophisticated 3D experimental platforms that mimic natural habitats - soil, mucus, tissues - to study cellular physiology, behavior, and identity across diverse mechano-chemical milieus. These tools allow me to explore some of the most exciting new questions in biophysics and cell biology.

 

My work has yielded fundamentally unique insights on how microenvironments act as selective pressures on growth (Nature Communications, 2024), physically regulate cell division (bioRxiv, 2025), alter motility patterns (PRX Life, 2025), dictate morphological transitions (Small, 2025), influence pathogenesis (bioRxiv, 2025) and reprogram internal cellular states (bioRxiv, 2026).

Together, my research demonstrates how purely physical environmental properties potently influence living systems - independent of species identity or molecular pathways. These efforts advance a key interdisciplinary paradigm - that even complex biological systems can be dissected using engineered platforms and elegant physical models, revealing unprecedented insights on the design principles of life.

The scientific views and opinions expressed in this website are solely personal and do not necessarily reflect the position of the ESoftbio Lab, funding agencies, or NCBS. While this website uses logos of NCBS and TIFR, it is an externally owned and run website for which NCBS does not take any responsibility. Personal information of the members are shared for professional purposes ONLY and should NOT be used otherwise.

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